Wisniowska B, Tylutki Z, Polak S. Thorough QT (TQT) studies: Concordance with torsadogenesis and evolving cardiac safety testing paradigm. Drug Discovery Today, 2017, In press.
Tylutki Z, Polak S. A four-compartment PBPK heart model accounting for cardiac metabolism - model development and application. Nature Scientific Reports, 2017, Scientific Reports 7, Article number: 39494.
Abbasi M, Patel N, Small B, Jamei M, Polak S. Early assessment of pro-arrhythmic risk of drugs using the in vitro data and single cell based in silico models: proof of concept Toxicology Mechanisms and Methods, 2017, 27(2):88-99.
Wisniowska B, Polak S. So am I or am I not proarrhythmic? Comparison of various classifications of drugs TdP propensity. Drug Discovery Today, 2017,22(1):10–16.
Wisniowska B, Polak S. The role of interaction model in simulation of drug interactions and QT prolongation Current Pharmacology Reports, 2016,2(6): 339-344.
Wisniowska B, Polak S. Virtual clinical trial towards polytherapy safety assessment – combination of PBPK/PD based modelling and simulation approach with DDIs involving terfenadine as an example. Journal of Pharmaceutical Sciences, 2016,105(11): 3415-3424.
Tylutki Z, Polak S, Wisniowska B. Top-down, Bottom-up and Middle-out Strategies for Drug Cardiac Safety Assessment via Modeling & Simulations. Current Pharmacology Reports, 2016,2(14): 171-177.
Wisniowska B, Tylutki Z, Wyszogrodzka G, Polak S. Drug-drug interactions and QT prolongation as a commonly assessed cardiac effect - comprehensive overview of clinical trials. BMC Pharmacology and Toxicology, 2016,17(12).
Tylutki Z, Polak S. The effect of increasing amitriptyline doses on cardiomyocytes’ electrophysiology – simulation study.
Badyra B, Lisowski B, Polak S, Kudolo J, Wiśniowska B. How in vitro influences in silico utilized for the prediction of in vivo — pilot study of the drug-induced pro-arrhythmic potency prediction. Folia Medica Cracoviensia, 2015,LV(4): 5-19.
Mendyk A, Güres A, Jachowicz R, Szlęk J, Polak S, Wisniowska B, Kleinebudde P. From Heuristic to Mathematical Modeling of Drugs Dissolution Profiles: Application of Artificial Neural Networks (ANNs) and Genetic Programming (GP). Computational and Mathematical Methods in Medicine, 2015, Article ID 863874.
Culen M, Tuszyński PK, Polak S, Jachowicz R, Mendyk A, Dohnal J. Development of In Vitro-In Vivo Correlation/Relationship Modeling Approaches for Immediate Release Formulations Using Compartmental Dynamic Dissolution Data from ‘‘Golem’’: A Novel Apparatus). BioMed Research International, 2015, Article ID 328628.
Polak S, Pugsley MK, Stockbridge N, Garnett C, Wisniowska B. Early Drug Discovery Prediction of Proarrhythmia Potential and Its Covariates. AAPS Journal, 2015; 17(4): 1025-1032.
Tylutki Z, Polak S. Plasma vs. heart tissue concentration in humans – literature data analysis of drugs distribution. Biopharmaceutics and Drug Disposition, 2015; 36(6): 337–351.
Glinka A, Polak S. QTc modification after risperidone administration – insight into the mechanism of action with use of the modeling and simulation at the population level approach. Toxicology Mechanisms and Methods, 2015; 25(4): 279-286.
Wisniowska B, Mendyk A, Szlęk J, Kołaczkowski M, Polak S. Enhanced QSAR models for drug-triggered inhibition of the main cardiac ion currents. Journal of Applied Toxicology, 2015; 35(9): 1030–1039.
Mishra H, Polak S, Jamei M, Rostami-Hodjegan A. Interaction Between Domperidone and Ketoconazole: Toward Prediction of Consequent QTc Prolongation Using Purely In Vitro Information. CPT Pharmacometrics Syst. Pharmacol., 2014; 3, e130.
Fijorek K, et al. Model of the distribution of diastolic left ventricular posterior wall thickness in healthy adults and its impact on the behavior of a string of virtual cardiomyocytes. Journal of Cardiovascular Translational Research, 2014; 7(5): 507-517.
Fijorek K, Püsküllüoglu M, Tomaszewski R, Tomaszewska D, Glinka A, Polak S. Serum potassium, sodium and calcium levels in healthy individuals – literature review and data analysis. Folia Medica Cracoviensia, 2014; LIV(1): 53-70.
Glinka A, Polak S. The Effects of Six Antipsychotic Agents on QTc - an attempt to mimic clinical trial through simulation including variability in the population. Computers in Biology and Medicine, 2014; 7:20-26.
Wisniowska B, Mendyk A, Fijorek K, Polak S. Computer-based prediction of the drug proarrhythmic effect - problems, issues, known and suspected challenges Europace, 2014, 16:724-735.
Polak S, Wisniowska B, Fijorek K, Glinka A, Mendyk A. In vitro - in vivo extrapolation of drug-induced proarrhythmia predictions at the population level. Drug Discovery Today, 2014; 19:275-281.
Glinka A, Polak S. An analysis of cardiomyocyte electrophysiology in the presence of hERG gene mutations. Bio-Algorithms and Med-Systems, 2013; 9(3):135-140.
Fijorek K, Püsküllüoglu M, Polak S. Circadian models of serum potassium, sodium and calcium concentrations in healthy individuals, and their application to cardiac electrophysiology simulations at individual level. Computational and Mathematical Methods in Medicine, 2013; Article ID 429037, 8 pages, 2013. doi:10.1155/2013/429037.
Mendyk A, Tuszyński P, Polak S, Jachowicz R. In vitro-in vivo relationship (IVIVR) generalized model based on artificial neural networks. Journal of Drug Design, Development and Therapy, 2013;7:223-232.
Fijorek K, Patel N, Klima Ł, Stolarz-Skrzypek K, Kawecka-Jaszcz K, Polak S. Age and gender dependent heart rate circadian model development and performance verification on the proarrhythmic drug case study. Theoretical Biology and Medical Modelling, 2013;10:7.
Polak S. In vitro to human in vivo translation – pharmacokinetics and pharmacodynamics of quinidine. ALTEX, 2013;3(30):309-318.
Glinka A, Polak S. Wild type and K897T polymorphisms of the hERG gene: modeling the AP in Caucasians. Bioinformation, 2012;8(22):1062-1065.
Polak S, Wisniowska B, Glinka A, Polak M. tox-database.net - data describing the chemicals triggered in vitro cardiac ionic channels inhibition. BMC Pharmacology and Toxicology, 2012;13(6).
Wisniowska B, Mendyk A, Fijorek K, Glinka A, Polak S. Predictive model for the L-type channel inhibition - multichannel block in QT prolongation risk assessment. Journal of Applied Toxicology, 2012;32(10):858-866.
Polak S, Fijorek K. Inter-individual variability in the pre-clinical drug cardiotoxic safety assessment - analysis of the age - cardiomyocytes electric capacitance dependence. Journal of Cardiovascular Translational Research, 2012;5(3):321-332.
Polak S, Wisniowska B, Glinka A, Fijorek K, Mendyk A. Slow delayed rectifying potassium current (IKs) – analysis of the in vitro inhibition data and predictive model development. Journal of Applied Toxicology, 2013;33(8):723-739.
Polak S, Fijorek K, Glinka A, Wisniowska B, Mendyk A. Virtual population generator for human cardiomyocytes parameters. In silico drug cardiotoxicity assessment. Toxicology Mechanisms and Methods, 2012;22(1):31-40.
Fijorek K, Fijorek D, Wisniowska B, Polak S. BDTcomparator: a program for comparing binary classifiers. Bioinformatics, 2011;27(24):3439-3440.
Fijorek K, Fijorek D. The effectiveness of best subset variable selection in Firth logistic regression. Applied Informatics Methods, 2012;2(27):15-24.
Polak S, Wisniowska B, Fijorek K, Glinka A, Polak M, Mendyk A. The open-access dataset for in silico cardiotoxicity prediction system. Bioinformation, 2011;6(6):244-245.
Polak S, Wisniowska B, Ahamadi M, Mendyk A. Prediction of the hERG potassium channel inhibition potential with use of Artificial Neural Networks. Applied Soft Computing, 2011;11(2):2611-2617.
Wisniowska B, Mendyk A, Polak M, Szlek J, Polak S. Random Forest based assessment of the hERG channel inhibition potential for the early drug cardiotoxicity testing. Bio-Algorithms and Med-Systems, 2010;6(12):131-136.
Wisniowska B, Polak S. hERG in vitro interchange factors - development and verification. Toxicology Mechanisms and Methods, 2009;19(4):278-284.
Polak S, Wisniowska B, Brandys J. Collation, assessment and analysis of literature in vitro data on hERG receptor blocking potency for subsequent modeling of drugs cardiotoxic properties. Journal of Applied Toxicology, 2009;29(3):183-206.
Books / Proceedings / Conference presentations
Viceconti M, Henney A, Morley-Fletcher E. in silico Clinical Trials: ￼￼￼How Computer Simulation will Transform the Biomedical Industry. Research and Technological Development Roadmap, Avicenna Consortium, Brussels Jan 2016.
Wiśniowska B, Badyra B, Lisowski B, Polak S. To sum or not to sum - how to assess torsadogenic potential of combination of drugs and their active metabolites. In vitro assessment with loratadine and desloratadine as the exemplary drugs. Safety Pharmacology Society, Annual Meeting, 28.09-1.10.2015, Prague, Czech Republic.
Wiśniowska B, Badyra B, Lisowski B, Polak S, Glinka A. Systems pharmacology based approach utilized for prediction of the cardiac consequences of drug-drug interactions. Safety Pharmacology Society, Annual Meeting, 28.09-1.10.2015, Prague, Czech Republic.
Polak S. 13th European International Society for the Study of Xenobiotics (ISSX) Meeting June 22 - 25, 2015 in Glasgow, Scotland.
Polak S. IVIV and/or animal/human translations. EUFEPS Annual Meeting 2015 - System Approaches for Better Medicines and Health. 15-17 June 2015, Geneva, Switzerland. Tuesday June 16, Session II: Drug development - predictive toxicology, predictive translations.
Wiśniowska B. Evaluation of the ability of computational IVIV extrapolation to assess pharmacokinetic (Cmax/AUC) and pharmacodynamic (QTc) consequences of drug-drug interactions with cisapride and clarithromycin as exemplary drugs. EUFEPS Annual Meeting 2015 - System Approaches for Better Medicines and Health. 15-17 June 2015, Geneva, Switzerland. Tuesday June 16, Session II: Drug development - predictive toxicology, predictive translations.
Polak S. Physiological-Based Cardiomyocyte Model: Predicting QT Changes in Humans. 2015 ASCPT Annual Meeting. 03-07 March 2015, New Orleans, USA. Tuesday March 3, QUANTITATIVE SYSTEMS PHARMACOLOGY: MULTISCALE MODEL-BASED DRUG DEVELOPMENT THROUGH INTEGRATING SYSTEMS BIOLOGY AND PHARMACOMETRICS.
Polak S. Simulating cardiac consequences of the genetic variability at the metabolism level with use of middle-out approach and flecainide as an example compound. 2015 ASCPT Annual Meeting. 03-07 March 2015, New Orleans, USA. POSTER SESSION.
Polak S, Tylutki Z, Wiśniowska B, Rostami-Hodjegan A. Simulating pharmacokinetic and pharmacodynamic impact of the drug formulation on the human cardiac safety by applying in vitro - in vivo extrapolation approach. AAPS Annual Meeting and Expoition; San Diego, USA; 2-6.11.2014
Patel N., Jamei M., Rostami Hodjegan A., Polak S. Prediction of QT changes in humans incorporating in vitro data into physiologically based cardiomyocyte cell model - a case study on inhibition of multiple cardiac ion currents by tolterodine and its metabolite. 2013 AAPS Annual Meeting and Exposition. 10-14 November 2013, San Antonio, USA. POSTER T3221. Session Date: Tuesday, November 12, 2013 Session Time: 01:30 pm - 04:30 pm.
Small B., et al. Pharmacokinetic (PK) and Pharmacodynamic (PD) Implications of Diurnal Variation of Gastric Emptying and Small Intestinal Transit Time for Quinidine Mechanistic Simulation. BSTP 28th Annual Scientific Meeting held jointly with the Safety Pharmacology Society. Thursday 14th and Friday 15th November 2013; Alderley Park, Cheshire, UK.
Glinka A., Wiśniowska B. hERG channel trafficking mutations – their role in the drug triggered arrhythmia. Simulation study. BSTP 28th Annual Scientific Meeting held jointly with the Safety Pharmacology Society. Thursday 14th and Friday 15th November 2013; Alderley Park, Cheshire, UK.
Symposium on Cardiac Safety Simulator, Sheffield, UK, 19-20 September 2013.
Polak S., Tomaszewska D., Patel N., Jamei M., Rostami-Hodjegan A. Pharmacokinetic (PK) and pharmacodynamic (PD) implications of diurnal variation of gastric emptying and small intestinal transit time for quinidine: A mechanistic simulation. PAGE conference, 11-14 June 2013, Glasgow, Scotland.
Polak S. In Vitro to Human In Vivo Translation – Proarrhythmic Potency of Dofetilide. 8th Annual International Conference on Predictive Human Toxicity and ADME/Tox Studies January 24th - 25th, 2013 Brussels, Belgium.
4th Workshop on using Computational Methods in Pharmaceutical Sciences was a one day long training which took place on 8th of September, 2012 in Krakow, Poland as a part of the Computing in Cardiology Conference - CinC 2012. The main goal of the Workshop was to provide in depth, practical information about design, development, validation and implementation of the computational methods used in the pharmaceutical sciences with focus put on the early drugs cardiotoxicity prediction. Video materials from the event will be available soon.
Polak S, Wisniowska B, Fijorek K, Glinka A, Polak M, Mendyk A. In silico prediction of the drug overdose consequences at the heart electrophysiology level. Computing in Cardiology; September 9-12, 2012; Krakow, Poland. Full text in Computing in Cardiology, 2012;39:889-893.
Polak S, Wisniowska B, Fijorek K, Glinka A, Polak M, Mendyk A. ToxComp ‐ in vitro–in vivo extrapolation system for the drugs proarrhythmic potency assessment. Computing in Cardiology; September 9-12, 2012; Krakow, Poland. Full text in Computing in Cardiology, 2012;39:789-793.
Polak S, Wisniowska B, Fijorek K, Glinka A, Polak M, Mendyk A. Modeling and Simulation Approach for Assessing Proarrhythmic Potency of the Non‐cardiological Drugs. Computing in Cardiology; September 9-12, 2012; Krakow, Poland. Full text in Computing in Cardiology, 2012;39:761-765.
Mendyk A, Wisniowska B, Fijorek K, Glinka A, Polak M, Polak S. Empirical modeling of the sodium channel inhibition caused by drugs. Computing in Cardiology; September 9-12, 2012; Krakow, Poland. Full text in Computing in Cardiology, 2012;39:293-297.
48th EUROTOX Congress took place in Stockholm, Sweden (17-20 of June, 2012). Team achievements were presented as the scientific posters: "Influence of the physiological parameters on the APD90 value simulated by human ventricular tissue model" and "Electrophysiologically inactive drugs - can we predict their cardiotoxicity?". They both were presented during the Session P07 Computational toxicology.
Mishra H, Jamei M. Rostami-Hodjegan M, Polak S. Model-Based Prediction of Domperidone and Ketoconazole Interaction and its Impact on QTc Prolongation. 21st PAGE meeting; June 5th - tth, 2012; Venice, Italy.
11th World Pharma Congress was a one day long training which took place in Philadelphia, PA (5-7 of June, 2012). On Tuesday 5th of June Dr Sebastian Polak gave presentation "In vitro-in vivo Extrapolation of the Cardiotoxic Effect: Inter-Individual Variability Matters!".
Polak S., Wiśniowska B., Polak M., Szlęk J., Glinka A., Fijorek K. Mendyk A., ToxComp 1.2 – an Open Source iv vitro in vivo extrapolation (IVIVE) system for cardiotoxicity prediction with Marvin plugins embedded. ChemAxon UGM Budapest 2012, May 22-23, Budapest.
Polak S, Mishra H. Combining In Vitro-In Vivo Extrapolation (IVIVE) and Physiologically-Based Pharmacokinetics (PBPK) with Drug Related Risk Assessment - Cardiotoxicity prediction. 7th Annual International Conference on Predictive Human Toxicity and ADME/Tox Studies; January 26th - 27th, 2012; Brussels, Belgium.
The 16th Online World Conference on Soft Computing in Industrial Applications (WSC16); December 5th - 16th, 2011 INTERNET! Team achievements were presented during the special session - Special Session on Soft Computing Methods in Pharmaceutical and Medical Sciences.
On-line workshop 3rd International Workshop - Computational Pharmacy; September 22nd, 2011; Krakow, Poland (Internet!).
Polak S, Glinka A, Wisniowska B, Mendyk A. Influence on the physiological parameters on the ADP90 value simulated by human venrticular tissue model. Eurotox 2011, August 28th - 31st; Paris, France.
Half day long workshop Tox IVIVE - inter-individual variability matters! September 14th - 16th 2011; Berlin, Germany. All materials are available for download here.
Polak S. Optimization of the use of information for in vitro and in silico to predict in vivo Computational toxicology - in silico drug safety assessment during the 3rd Annual Predictive Toxicology; September 14th - 16th 2011; Berlin, Germany.
Mini-symposium Computational toxicology - in silico drug safety assessment during the 3rd Annual Predictive Toxicology; 14-16 September 2011; Berlin, Germany.
Mini-symposium Computational toxicology and pharmacology - in silico drug activity and safety assessment (Saturday, July 2, 11:00) during the 8-th European Conference on Mathematical and Theoretical Biology and Annual Meeting of The Society for Mathematical Biology; June 28th - July 2nd 2011, Krakow, Poland.
Sebastian Polak, Aleksander Mendyk. Computational toxicology. In silico assessment of the hERG channel inhibition potential for the early drug cardiotoxicity testing. Chemaxon 2011 European UGM, Training day and Markush Forum, May 16-19, Budapest, Hungary.
Sebastian Polak, Barbara Wisniowska, Kamil Fijorek, Anna Glinka, Miłosz Polak, Aleksander Mendyk. ToxComp - in silico platform for the cardiotoxicity assessment – in vitro-in vivo extrapolation. Applied Pharmaceutical Toxicology Workshop; May 18 - 20 2011; San Francisco, CA, USA.
Sebastian Polak. Combining systems biology and pharmacokinetics - drug cardiotoxicity assessment. 2011 CellML Workshop. Auckland, 11-12.04.2011 (on line presentation).
Sebastian Polak, Barbara Wisniowska, Malidi Ahamadi, Aleksander Mendyk. Prediction of the hERG potassium channel inhibition potential with use of the artificial neural networks. Soft Computing in Industrial Applications. Algorithms, Integration and Success Stories. In Advances in Intelligent and Soft Computing vol. 75 Eds. Gao X-Z, Gaspar-Cunha A., Koeppen M., Schaefer G., Wang J. Springer, Berlin 2010.
Barbara Wisniowska, Aleksander Mendyk, Milosz Polak, Jakub Szlek, Sebastian Polak. RandomForest based assessment of the hERG channel inhibition potential for the early drug cardiotoxicity testing (polish/english). MCSB 2010, Krakow 21-22.05.2010.
Sebastian Polak, Barbara Wisniowska, Malidi Ahamadi, Aleksander Mendyk. Prediction of the hERG potassium channel inhibition potential with use of the artificial neural networks. 14th Online World Conference on Soft Computing in Industrial Applications (WSC14), 17-29.11.2009.
Sebastian Polak. Modelling and simulations in modern pharmacy – bridging regulatory bodies, academia and industry. 3rd BBBB-Bosphorus International Conference on Pharmaceutical Sciences, Antalya, Turkey 26-28.10.2009; European Journal of Pharmaceutical Sciences 2009, vol. 38, Issue 1, Supplement.
Barbara Wisniowska, Sebastian Polak. Cardiotoxicity prediction algorithms. 1st International Workshop Computational Pharmacy, Krakow 19.06.2009.
Sebastian Polak, Barbara Wisniowska, Jerzy Brandys. Decision trees algorithms for the in silico prediction of hERG potassium channels inhibition (in polish). Polish Society of Toxicology Workshop “New trends in toxicology”, Lodz 1-2.06.2009.
Barbara Wisniowska, Sebastian Polak, Jerzy Brandys. Bayesian classification methods for proarrhythmic liability prediction. 5th German-Polish Symposium “New Challenges for Pharmaceutical Sciences”, Poznan 15-16.05.2009.
Sebastian Polak, Barbara Wisniowska, Jerzy Brandys. Modelling and simulation in the drug discovery, research and development. Toxicity prediction. 5th German-Polish Symposium “New Challenges for Pharmaceutical Sciences”, Poznan 15-16.05.2009.
Barbara Wisniowska, Sebastian Polak, Jerzy Brandys. Extrapolating factors for different in vitro hERG systems. Central European Congress of Life Science EUROBIOTECH 2008, Kraków 17-19.10.2008; Acta Biochimica Polonica 2008, vol. 55 suppl. 4.
We will be presenting
Polak S, Fijorek K, Püsküllüoğlu M, Glinka A, Tomaszewska D, Tomaszewski R. Literature review of the serum potassium, sodium and calcium levels in healthy individuals. Technical Note, 2013; 001.
We were cited
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Turner JR et al. Postmarketing Cardiovascular Safety Considerations. Turner JR, Karnad DR, Kothari S (eds): Cardiovascular Safety in Drug Development and Therapeutic Use. Switzerland, Springer, 2017.
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Blaauboer BJ, et al. Considering new methodologies in strategies for safety assessment of foods and food ingredients Food and Chemical Toxicology, 2016; 91:19–35.
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Bergenholm L, et al. PKPD modelling of PR and QRS intervals in conscious dogs using standard safety pharmacology data. Journal of Pharmacological and Toxicological Methods, 2016; 79: 34–44.
Zhang C, et al. In Silico Prediction of hERG Potassium Channel Blockage by Chemical Category Approaches. Toxicological Research, 2016; accepted for publication
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Poulin P. A Paradigm Shift in Pharmacokinetic–Pharmacodynamic (PKPD) Modeling: Rule of Thumb for Estimating Free Drug Level in Tissue Compared with Plasma to Guide Drug Design. Journal of Pharmaceutical Sciences, 2015; Vol.104 No.7: 2359-2368.
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Hardeland R. Melatonin and Circadian Oscillators in Aging - A Dynamic Approach to the Multiply Connected Players. Yashin AI, Jazwinski SM (eds): Aging and Health - A Systems Biology Perspective. Interdiscipl Top Gerontol. Basel, Karger, 2015, vol 40, pp 128-140, 2015.
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Kauthale RR, et al. Assessment of temperature-induced hERG channel blockade variation by drugs. Journal of Applied Toxicology, 2014; EarlyView: Accepted 20th August.
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